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                 您的位置是:論文中心 -> 基礎科 -> 異體脫細胞真←皮基質作為組織工程皮膚真皮支架的〗可行性
                異體脫細胞真皮基質⌒作為組織工程皮膚真皮支架的看大家可行性
                發布時間:2018-08-30 15:02:57 來源:知網 瀏覽次數:376 
                關鍵詞: 脫細胞真皮基質;真皮組織;皮膚替代物;生物相∩容性㊣ ;生物材料
                作者: 劉 坡1,祁少海2,舒 斌2,謝舉臨2,徐盈斌2,劉旭盛2
                作者單位:
                摘要:
                組織工程皮那你們可以想想后果會如何膚是目前研究皮膚損傷修復重建的重要手段之△一,異體脫細胞真皮基質不存在免疫原性,在異№體移植時不會發生排斥反應,是比較◆理想的真皮替代物。
                詳細內容:

                Abstract

                BACKGROUND: Tissue engineered skin has been used to repair defect skin. Acellular dermal matrix (ADM) had no immunogenicity, which cannot lead to rejection following transplantation, thus, this is an ideal dermal substitute for tissue engineered skin.

                OBJECTIVE: To explore the biocompatibility of ADM.

                METHODS: The histocompatibility, hydrophilicity and mechanical performance of ADM were detected by cytotoxicity test in vitro and vivo, equilibrium water content, swelling degree and biomechanical analysis.

                RESULTS AND CONCLUSION: No cell component was observed in the ADM. The ventage of ADM was 100- 180 μm in diameter. In the experimental group, equilibrium water content was (69.6±3.97)%, swelling degree was 2.3±0.42 and the breakage force was (3.082±0.046) N. There was no significant difference between experimental and control groups (P > 0.05). It was indicated that in cytotoxicity test, no inhibition effect on dermal papilla cells in vitro and no severe immunological rejection in vivo was found. The selected ADM could be an optimal biological material as a substitute of dermal with good histocompatibility, low immunogenicity and moderate mechanical performance.

                Liu P, Qi SH, Shu B, Xie JL, Xu YB, Liu XS. Feasibility of acellular dermal matrix as a dermal substitute in tissue engineering. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(21)3864-3868. [http://www.crter.cnhttp://en.zglckf.com]

                1.The First Department of Surgery, Tangxia Hospital, Dongguan 523721, Guangdong Province, China;

                2.Department of Burns, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China

                Liu Po★, Master, the First Department of Surgery, Tangxia Hospital, Dongguan 523721, Guangdong Province, China zsylper@ yahoo.com.cn

                Corresponding author: Qi Shao-hai,Master, Professor, Doctoral supervisor,Department of Burns,the First Affiliated Hospital, Sun Yat-sen University,Guangzhou 510080, Guangdong Province, China qishaohai@ yahoo.com.cn

                Supported by: the Scientific and Technological Foundation of Guandong Province,

                2010B031100008*

                Received: 2011-11-01

                  Accepted: 2012-01-07

                摘要

                背景:組織工程皮膚是目前研究皮膚損傷修復重建的重要手段之 一,異體脫細胞真皮基質不存在免疫原性,在異體移植時不會發生排斥反@ 應,是比較理想的真皮替∑ 代物。

                目的:觀察異體脫細胞☆真皮基質的組點了點頭織相容性。

                方法:以正常人體真皮▼組織作為對照,通過體外、體內細〖胞毒性實驗檢測異體脫細胞真皮基質的組織相容性,以膨脹度、飽和含死不瞑目水量及生物力學分析檢測異體脫細胞真皮基質的親水○性及機械性能。

                結果與結論:真皮基質中未見任何細胞成分,其網孔◤直徑介於 100~180 μm之間。脫細胞真皮

                中國黑色背心黑光閃爍組織工程研究▆ 第 16 卷 第 21 期 2012-05-20 出版


                基質組飽和含水量為ㄨ(69.6±3.97)%,膨脹度 2.30±0.42,最大斷裂力為(3.082±0.046) N,與對照組相比,差異無顯著性意義(P > 0.05)。體內外細胞毒性檢測,未見明顯¤細胞生長抑制及免疫排斥反應。提示異體脫細胞真皮基質機械性能接近々正常皮膚,組織相容性◥好,免疫排斥反應小,是構建組織工程皮膚理想的□真皮材料。

                關鍵詞:脫細胞真皮基質;真皮組織;皮膚替代物;生物相容外三層性;生物材料

                doi:10.3969/j.issn.1673-8225.2012.21.015

                縮略語:EWC:equilibrium water content,飽和含水量

                劉坡,祁少海,舒斌,謝舉臨,徐盈斌,劉旭盛. 異體脫細胞真★皮基質作為組織工程皮膚真皮支架的可行性[J].中國組織工程研究,2012 16(21):3864-3868. [http://www.crter.orghttp://cn.zglckf.com]

                  


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